Retatrutide reconstitution calculator
Calculate exact reconstitution volumes for each retatrutide protocol dose. Based on the Phase 3 escalation schedule: 1mg → 2mg → 4mg → 8mg → 12mg weekly.
Phase 3 protocol note
Retatrutide Phase 3 trial used pre-filled auto-injector pens. Research vials require manual reconstitution. Starting dose is 1 mg/week, escalating every 4 weeks to a maximum of 12 mg/week.
Dose
1 mg
1,000 mcg
Concentration
2.50 mg/mL
2500 mcg/mL
Inject
0.400 mL
40 units (U-100)
Doses per vial
5
5mg vial at 1mg/dose
Storage guidance
Store lyophilized retatrutide at −20°C. After reconstitution with bacteriostatic water, refrigerate at 2–8°C. Use within 28 days. Avoid freeze-thaw cycles. Inject subcutaneously into abdomen, thigh, or upper arm — rotate sites weekly.
Research use only. This calculator is provided for educational and research purposes only. It does not constitute medical advice. Consult a licensed physician before use.
References
Jastreboff AM, Kaplan LM, Frías JP, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine. DOI: 10.1056/NEJMoa2301972