Peptides
TB-500
Thymosin Beta-4 Fragment (Tβ4)
Category
Healing peptide
Half-life
~4–5 days
Typical dose
2.5–5 mg
Frequency
2× per week
Route
Subcutaneous or intramuscular
Mechanism
TB-500 is a synthetic analogue of thymosin beta-4, a naturally occurring peptide found in high concentrations at sites of tissue injury. It promotes actin upregulation — actin being a protein critical to cell structure and migration. This drives cell migration to injury sites, promotes angiogenesis (new blood vessel formation), and reduces inflammation. Often stacked with BPC-157 for synergistic healing effects.
Research summary
Animal studies demonstrate significant healing acceleration in tendon, muscle, cardiac, and corneal tissue. TB-500 has shown particular promise in cardiac repair research — myocardial infarction models show reduced scar tissue and improved cardiac function. Human clinical data is sparse. Most evidence comes from animal models.
Storage
Lyophilized: −20°C. Reconstituted: 2–8°C up to 4 weeks.
Key studies
Goldstein AL, et al. (2012). Thymosin beta4: a multi-functional regenerative peptide. Expert Opinion on Biological Therapy. DOI: 10.1517/14712598.2012.634793
Frequently asked questions
What is TB-500 used for?
TB-500 is researched for tissue repair — particularly tendon, muscle, and cardiac healing. It is frequently stacked with BPC-157 for synergistic regenerative effects.
What is the difference between TB-500 and BPC-157?
BPC-157 works primarily through growth hormone receptor upregulation and nitric oxide pathways. TB-500 works through actin regulation and cell migration. They have complementary mechanisms and are commonly stacked together.
How long does TB-500 stay in your system?
TB-500 has a half-life of approximately 4–5 days, significantly longer than BPC-157. Once-weekly or twice-weekly dosing is typical in research protocols.
For research use only. Not intended for human consumption. Not medical advice. Consult a licensed physician before use.