Peptides
Sermorelin
GHRH (1-29) Fragment
Category
GH peptide
Half-life
~10–20 minutes
Typical dose
200–500 mcg
Frequency
Once daily (pre-sleep)
Route
Subcutaneous injection
Mechanism
Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone releasing hormone (GHRH 1-29). It binds pituitary GHRH receptors and stimulates GH release through natural physiological pathways — the pituitary retains control over the GH pulse, meaning it cannot produce supraphysiological GH levels. This makes sermorelin one of the most conservative GH-stimulating research peptides.
Research summary
Sermorelin is FDA-approved for GH deficiency in children. In adults it is used off-label and in research contexts. Its short half-life means pre-sleep dosing is required to capture the natural GH pulse window.
Storage
Lyophilized: −20°C. Reconstituted: 2–8°C up to 4 weeks.
Key studies
Walker RF. (2006). Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging. DOI: 10.2147/ciia.2006.1.4.307
Frequently asked questions
Is sermorelin safer than HGH?
Sermorelin stimulates the pituitary to produce GH naturally, meaning GH levels remain under physiological control. Direct HGH administration bypasses this control. Most researchers consider sermorelin a more conservative approach to GH optimization.
When should sermorelin be dosed?
Pre-sleep dosing — 30 minutes before bed — is standard. The body's largest natural GH pulse occurs during slow-wave sleep. Sermorelin amplifies this pulse. Fast for 2–3 hours before dosing.
For research use only. Not intended for human consumption. Not medical advice. Consult a licensed physician before use.