Peptides
Kisspeptin-10
HPG Axis Stimulator
Category
Neuropeptide
Half-life
~28 min (IV)
Target
GPR54 / KISS1R
Route
Subcutaneous / IV
Kisspeptin-10 (KP-10) is a 10 amino acid fragment of the kisspeptin family that acts as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates GnRH release from the hypothalamus, driving pulsatile LH secretion and downstream testosterone production. Unlike exogenous testosterone, kisspeptin-10 works upstream — stimulating the body\'s own hormonal cascade rather than replacing it.
Frequently asked questions
What does kisspeptin-10 do?+
Kisspeptin-10 activates GPR54 receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This drives LH and FSH secretion from the pituitary, which stimulates testicular testosterone production and ovarian function. It is the upstream master regulator of the entire reproductive hormone axis.
How is kisspeptin-10 different from testosterone replacement?+
Testosterone replacement (TRT) bypasses the HPG axis entirely, suppressing natural production. Kisspeptin-10 works upstream — stimulating your own hormonal cascade through the hypothalamus and pituitary. This preserves the pulsatile, physiological pattern of hormone release and maintains testicular function and fertility.
What is the half-life of kisspeptin-10?+
Kisspeptin-10 has a very short half-life of approximately 28 minutes via intravenous administration, and somewhat longer subcutaneously. The short half-life is relevant to dosing frequency — pulsatile administration mimics the natural GnRH secretion pattern more accurately than continuous infusion.
Is kisspeptin-10 FDA approved?+
Kisspeptin-10 is not FDA approved. It is used in clinical research to study reproductive endocrinology and hormonal disorders. It has been used in academic clinical trials for hypogonadism, hypothalamic amenorrhea, and fertility research.
Can kisspeptin-10 restore natural testosterone production?+
Research in hypogonadal men shows kisspeptin-10 can restore LH pulsatility and increase testosterone levels by stimulating the HPG axis. It is of particular research interest for men with hypothalamic hypogonadism where the deficit is upstream of the pituitary, and for fertility preservation during hormonal protocols.
Research tools
For research use only. This page is provided for educational purposes only and does not constitute medical advice. Consult a licensed physician before use.