Peptides
GHK-Cu
Glycyl-L-Histidyl-L-Lysine Copper
Category
Longevity peptide
Half-life
~30 minutes (systemic)
Typical dose
2 mg
Frequency
3× per week
Route
Subcutaneous injection or topical
Mechanism
GHK-Cu is a naturally occurring copper peptide found in human plasma, saliva, and urine. Plasma levels decline significantly with age. It activates over 4,000 genes — many related to tissue repair, collagen synthesis, and anti-inflammatory pathways. Research has identified roles in wound healing, skin repair, nerve regeneration, and stem cell activation. The copper ion is essential to its activity.
Research summary
GHK-Cu has extensive in vitro and animal model data supporting wound healing, collagen synthesis, and anti-inflammatory effects. Topical formulations are commercially used in skincare. Systemic injectable research is more limited. Loren Pickart's work established foundational mechanisms.
Storage
Lyophilized: −20°C. Reconstituted: 2–8°C up to 4 weeks.
Key studies
Pickart L, et al. (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. DOI: 10.1155/2015/648108
Frequently asked questions
What does GHK-Cu do?
GHK-Cu activates genes associated with tissue repair, collagen production, wound healing, and stem cell activation. Research suggests anti-inflammatory, antioxidant, and neuroprotective properties. It also activates genes that suppress cancer-related pathways.
Can GHK-Cu be applied topically?
Yes — topical GHK-Cu is widely used in cosmetic formulations for skin regeneration. Injectable systemic research uses subcutaneous administration for systemic effects.
For research use only. Not intended for human consumption. Not medical advice. Consult a licensed physician before use.