Peptides
Epithalon
Epitalon Tetrapeptide (Ala-Glu-Asp-Gly)
Category
Longevity peptide
Half-life
Short (hours)
Typical dose
10 mg
Frequency
10-day pulse, 2× per year
Route
Subcutaneous injection
Mechanism
Epithalon (epitalon) is a synthetic tetrapeptide derived from epithalamin — a natural peptide produced by the pineal gland. Research by Vladimir Khavinson established that epithalon activates telomerase, the enzyme that elongates telomeres. Telomere shortening is associated with cellular aging. Epithalon's proposed mechanism is slowing telomere attrition, potentially delaying cellular senescence.
Research summary
Russian longevity research by Khavinson and colleagues forms the bulk of the evidence base. Studies in animals and limited human cohorts suggest effects on telomere length, immune function, and pineal regulation. Most data comes from Russian institutions and has limited replication in Western literature. Used in longevity protocols as a periodic pulse rather than continuous administration.
Storage
Lyophilized: −20°C. Reconstituted: 2–8°C up to 4 weeks.
Key studies
Khavinson VK, et al. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. DOI: 10.1023/a:1025493705728
Frequently asked questions
How is epithalon administered?
Epithalon is typically used in pulse cycles — 10mg daily for 10 consecutive days, twice per year. Continuous daily dosing is not the standard research protocol.
What does epithalon do to telomeres?
Epithalon is proposed to activate telomerase, the enzyme responsible for elongating telomeres. Telomere shortening occurs with each cell division and is associated with aging. In vitro studies and limited animal data support telomerase activation. Human clinical data is sparse.
For research use only. Not intended for human consumption. Not medical advice. Consult a licensed physician before use.